| + |
MAPK3 | up-regulates 
phosphorylation
|
SREBF2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123049 |
Ser432 |
NQNVLLMsPPASDSG |
Homo sapiens |
|
| pmid |
sentence |
| 14988395 |
Insulin-activated erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo.Further characterization by electrophoretic mobility shift assay and promoter reporter gene analyses revealed that phosphorylation does not influence protein/dna interaction, but enhances trans-activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123053 |
Ser455 |
SIDSEPGsPLLDDAK |
Homo sapiens |
|
| pmid |
sentence |
| 14988395 |
Insulin-activated erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo.Further characterization by electrophoretic mobility shift assay and promoter reporter gene analyses revealed that phosphorylation does not influence protein/dna interaction, but enhances trans-activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | up-regulates
phosphorylation
|
SREBF2 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123041 |
Ser432 |
NQNVLLMsPPASDSG |
Homo sapiens |
|
| pmid |
sentence |
| 14988395 |
Insulin-activated erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo.Further characterization by electrophoretic mobility shift assay and promoter reporter gene analyses revealed that phosphorylation does not influence protein/dna interaction, but enhances trans-activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123045 |
Ser455 |
SIDSEPGsPLLDDAK |
Homo sapiens |
|
| pmid |
sentence |
| 14988395 |
Insulin-activated erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo.Further characterization by electrophoretic mobility shift assay and promoter reporter gene analyses revealed that phosphorylation does not influence protein/dna interaction, but enhances trans-activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MBTPS2 | up-regulates activity
cleavage
|
SREBF2 |
0.661 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267498 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 10419520 |
In order to activate transcription, the NH2-terminal domain of the SREBP must be released from the membrane so that it can enter the nucleus. This release has been studied most extensively for one of the SREBPs, namely, SREBP-2. However, the mechanism appears to be similar for the other SREBPs (SREBP-1a and -1c) (1). Release of the NH2-terminal domain is accomplished by a two-step proteolytic event that is regulated by sterols (3). In sterol-depleted mammalian cells, this proteolysis is initiated by the Site-1 protease (S1P), which cleaves human SREBP-2 between the Leu522-Ser523 bond in the sequence RSVL S (4). This cleavage requires formation of a complex between SREBP and SCAP, a polytopic membrane protein of the ER, and it is prevented when this complex is disrupted |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
SREBF2 | down-regulates quantity by repression 
transcriptional regulation
|
LRP1 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254461 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20980003 |
In the present study we report that specific silencing of either SREBP-1 or SREBP-2 enhanced LRP1 whereas overexpression of the active SREBP isoforms decreased LRP1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
PCSK9 |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255223 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17921436 |
Expression of nuclear forms of sterol-regulatory element binding protein-1 (SREBP-1) and SREBP-2 dramatically increased the promoter activity of PCSK9. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254459 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21123766 |
Recent studies have demonstrated that PCSK9 mRNA expression was upregulated to a greater extent than that of the LDL receptor in human hepatocytes in primary culture. Our findings also support the role of SREBP-2 as a transcriptional regulator of both the LDL receptor and PCSK9 in human enterocytes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
SND1 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259136 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29296233 |
These findings reveal that SREBP-2 and SREBP-1 bind to specific sites in SND1 promoter and regulate SND1 transcription in opposite ways; it is induced by SREBP-2 activating conditions and repressed by SREBP-1 overexpression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCAP | up-regulates activity
relocalization
|
SREBF2 |
0.898 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267502 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 12202038 |
SCAP contains two domains: an NH2-terminal membrane attachment domain with eight membrane-spanning helices (Nohturfft et al., 1998b) and a long COOH-terminal extension that contains multiple copies of a WD40 repeat sequence, which forms a propeller-like structure that binds to the COOH-terminal domains of the SREBPs, thereby permitting the escort function |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
SREBF2 | up-regulates quantity by expression 
transcriptional regulation
|
PON2 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255225 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19497963 |
UPA upregulated PON2 expression in a sterol regulatory binding protein-2 (SREBP-2)-dependent manner, since blocking SREBP-2 maturation by 4-(2-aminoethyl)-benzenesulfonyl fluoride abolished uPA-stimulation of PON2, whereas inhibition of SREBP-2 catabolism by N-acetyl-leucyl-norleucinal had an opposite effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | up-regulates
phosphorylation
|
SREBF2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270012 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14988395 |
Insulin-activated erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo.Further characterization by electrophoretic mobility shift assay and promoter reporter gene analyses revealed that phosphorylation does not influence protein/dna interaction, but enhances trans-activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
LDLR |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254453 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21123766 |
Recent studies have demonstrated that PCSK9 mRNA expression was upregulated to a greater extent than that of the LDL receptor in human hepatocytes in primary culture. Our findings also support the role of SREBP-2 as a transcriptional regulator of both the LDL receptor and PCSK9 in human enterocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253133 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12923220 |
IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells|evidence that IDH1 may regulate lipogenesis in hepatic cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
HMGCR |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265161 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31848472 |
The processed SREBP2, designated nuclear SREBP2 (nSREBP2), then enters the nucleus as a homodimer, binds to the sterol regulatory element (SRE) sequence in the promoters of target genes, including HMGCR and SQLE (encoding squalene monooxygenase), and upregulates their transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
PON1 |
0.302 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255224 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20728021 |
we conclude that quercetin exhibits its antiatherogenic property by eliciting the translocation of the mature SREBP2 from endoplasmic reticulum to the nucleus, where it binds to SRE-like sequence in the PON1 promoter and up-regulates PON1 gene transcription and PON1 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | down-regulates quantity by repression
transcriptional regulation
|
ABCG5 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254455 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21123766 |
these results indicate that HMG-CoAR inhibition with atorvastatin stimulates intestinal expression of NPC1L1 and PCSK9, increases cholesterol absorption, and reduces ABCG5/8 expression; these effects are mediated most likely by stimulation of the transcription factors SREBP-2 and HNF-4α. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MBTPS1 | up-regulates activity
cleavage
|
SREBF2 |
0.579 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267496 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 10644685 |
We present evidence that SKI-1 processes peptides mimicking the cleavage sites of the SKI-1 prosegment, pro-brain-derived neurotrophic factor, and the sterol regulatory element-binding protein SREBP-2 |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
NPC1L1 |
0.583 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254452 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21123766 |
Our results showed a positive correlation between changes in NPC1L1 and changes in both SREBP-2 and HNF-4α mRNA expression, a finding that supports the notion that these transcription factors stimulate intestinal NPC1L1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF139 | down-regulates quantity 
ubiquitination
|
SREBF2 |
0.491 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271958 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20068067 |
Induction of TRC8 destabilized the precursor forms of the transcription factors SREBP-1 and SREBP-2. TRC8 destablizes SREBP precursors in a RING and proteasome-dependent manner |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
SQLE |
0.579 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265162 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31848472 |
The processed SREBP2, designated nuclear SREBP2 (nSREBP2), then enters the nucleus as a homodimer, binds to the sterol regulatory element (SRE) sequence in the promoters of target genes, including HMGCR and SQLE (encoding squalene monooxygenase), and upregulates their transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| + |
ERK1/2 | up-regulates
phosphorylation
|
SREBF2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270141 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14988395 |
Insulin-activated erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo.Further characterization by electrophoretic mobility shift assay and promoter reporter gene analyses revealed that phosphorylation does not influence protein/dna interaction, but enhances trans-activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | down-regulates quantity by repression
transcriptional regulation
|
ABCG8 |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254456 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21123766 |
these results indicate that HMG-CoAR inhibition with atorvastatin stimulates intestinal expression of NPC1L1 and PCSK9, increases cholesterol absorption, and reduces ABCG5/8 expression; these effects are mediated most likely by stimulation of the transcription factors SREBP-2 and HNF-4α. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SREBF2
- 
- 