Summary

Name CEMIP2
Full Name Cell surface hyaluronidase
Synonyms EC 3.2.1.35, Cell migration-inducing hyaluronidase 2, Transmembrane protein 2 | KIAA1412, TMEM2
Primary ID Q9UHN6
Links - -
Type protein
Relations 1
Function Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172). {ECO:0000250|UniProtKB:A3KPQ7, ECO:0000269|PubMed:28246172}.

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Relations

Regulator Mechanism target score ℹ
+ MARCHF9down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CEMIP2 0.2
Publications: 1 Organism: Homo Sapiens