Summary

Name MED13
Full Name Mediator of RNA polymerase II transcription subunit 13
Synonyms Activator-recruited cofactor 250 kDa component, ARC250, Mediator complex subunit 13, Thyroid hormone receptor-associated protein 1, Thyroid hormone receptor-associated protein complex 240 kDa component, Trap240, Vitamin D3 receptor-interacting protein complex component DRIP250, DRIP250 | ARC250, KIAA0593, THRAP1, TRAP240
Primary ID Q9UHV7
Links - -
Type protein
Relations 3
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

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Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination MED13 0.299
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination MED13 0.38
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CKM complex 0.794
Publications: 1 Organism: Homo Sapiens