+ |
FBXW7 | down-regulates quantity by destabilization
ubiquitination
|
MED13 |
0.372 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266690 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
23322298 |
The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. We show that Fbw7, a tumor suppressor and ubiquitin ligase, binds to CDK8-Mediator and targets MED13/13L for degradation. MED13/13L physically link the CDK8 module to Mediator, and Fbw7 loss increases CDK8 module-Mediator association. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SCF-FBW7 | down-regulates quantity by destabilization
ubiquitination
|
MED13 |
0.295 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266691 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
23322298 |
The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. We show that Fbw7, a tumor suppressor and ubiquitin ligase, binds to CDK8-Mediator and targets MED13/13L for degradation. MED13/13L physically link the CDK8 module to Mediator, and Fbw7 loss increases CDK8 module-Mediator association. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CDK8 | down-regulates quantity by destabilization
phosphorylation
|
MED13 |
0.901 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279687 |
|
|
Homo sapiens |
|
pmid |
sentence |
29212878 |
Here, cyclin C-Cdk8 phosphorylation of Med13 most likely primes the phosphodegron for destruction. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MED13 | form complex
binding
|
CKM complex |
0.802 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266684 |
|
|
Homo sapiens |
|
pmid |
sentence |
23563140 |
The CDK8 kinase module (CKM) is a conserved, dissociable Mediator subcomplex whose component subunits were genetically linked to the RNA polymerase II (RNAPII) C-terminal domain (CTD) and individually recognized as transcriptional repressors before Mediator was identified as a pre-eminent complex in eukaryotic transcription regulation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |