Summary

Name RABGEF1
Full Name Rab5 GDP/GTP exchange factor
Synonyms RAP1, Rabaptin-5-associated exchange factor for Rab5, Rabex-5 | RABEX5
Primary ID Q9UJ41
Links - -
Type protein
Relations 4
Function Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ RABEP1up-regulates img/direct-activation.png binding RABGEF1 0.941
Publications: 1 Organism: Homo Sapiens
+ RABGEF1up-regulates img/direct-activation.png binding RAB5A 0.92
Publications: 1 Organism: Homo Sapiens
+ RABGEF1up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAB5A 0.92
Publications: 1 Organism: Mus Musculus
+ AP-1/clathrin vescicleup-regulates activity img/direct-activation.png relocalization RABGEF1 0.332
Publications: 1 Organism: Mus Musculus