Relation Results

Summary

Name CDC23
Full Name Cell division cycle protein 23 homolog
Synonyms Anaphase-promoting complex subunit 8, APC8, Cyclosome subunit 8 | ANAPC8
Primary ID Q9UJX2
Links - -
Type protein
Relations 2
Function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis an ...
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Type: Score: Layout: SPV 
0.6270.914CDK1CDC23APC-c

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK1up-regulates img/direct-activation.png phosphorylation CDC23 0.627
Identifier Residue Sequence Organism Cell Line
SIGNOR-119821 Thr565 NQGETPTtEVPAPFF Homo sapiens
pmid sentence
Apc activation is thought to depend on apc phosphorylation and cdc20 binding. We have identified 43 phospho_sites on apc of which at least 34 are mitosis specific. Of these, 32 sites are clustered in parts of apc1 and the tetratricopeptide repeat (tpr) subunits cdc27, cdc16, cdc23 and apc7. In vitro, at least 15 of the mitotic phospho_sites can be generated by cyclin_dependent kinase 1 (cdk1), and 3 by polo_like kinase 1 (plk1). Apc phosphorylation by cdk1, but not by plk1, is sufficient for increased cdc20 binding and apc activation
Publications: 1 Organism: Homo Sapiens
+ CDC23form complex img/form-complex.png binding APC-c 0.914
Identifier Residue Sequence Organism Cell Line
SIGNOR-252008
pmid sentence
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex.
Publications: 1
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