Relation Results

Summary

Name RPS6KA6
Full Name Ribosomal protein S6 kinase alpha-6
Synonyms S6K-alpha-6, EC 2.7.11.1, 90 kDa ribosomal protein S6 kinase 6, p90-RSK 6, p90RSK6, Ribosomal S6 kinase 4, RSK-4, pp90RSK4 | RSK4
Primary ID Q9UK32
Links - -
Type protein
Relations 3
Function Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dep ...
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Type: Score: Layout: SPV 
0.20.2540.2RPS6KA6EP300GSK3B

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ RPS6KA6up-regulates activity img/direct-activation.png phosphorylation RPS6KA6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275797 Ser232 DQEKKAYsFCGTVEY
pmid sentence
These mutants had minimal kinase activity and showed profoundly decreased phosphorylation at Ser232 compared with wild-type RSK4 (Fig 10B), suggesting that RSK4 can autophosphorylate at Ser232.
Publications: 1
+ RPS6KA6down-regulates activity img/direct_inhibition.png phosphorylation EP300 0.254
Identifier Residue Sequence Organism Cell Line
SIGNOR-275796 Ser89 SELLRSGsSPNLNMG
pmid sentence
Figure 2G shows that Ser89 phosphorylation of p300, an event that inhibits p300’s acetyltransferase activity (13), was decreased in RSK4-silenced A549 and T24 cells. Consequently, RSK4 may regulate the activity of the NFκB pathway by direct phosphorylation of p300, as recombinant RSK4 phosphorylates p300 on Ser89 in vitro 
Publications: 1
+ RPS6KA6down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275801 Ser9 SGRPRTTsFAESCKP
pmid sentence
Moreover, RSK4 stabilized Beta-catenin in the presence of GSK-3Beta WT but not RSK4 stabilizes Beta-catenin through phosphorylation of GSK-3Beta (Ser9) in ESCC cells|GSK-3Beta S9A in ESCC cells, which was similar to overexpression of GSK3Beta S9D|
Publications: 1
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