| + |
GSK3B | down-regulates activity 
phosphorylation
|
AKAP11 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264816 |
Thr1136 |
AKEFAPAtPPSTPHN |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26088133 |
A-kinase anchoring protein 220 (AKAP220) is a multivalent anchoring protein that can sequester a variety of signal transduction enzymes. These include protein kinase A (PKA) and glycogen synthase kinase 3beta (GSK3beta). Using a combination of molecular and cellular approaches we show that GSK3beta phosphorylation of Thr-1132 on AKAP220 initiates recruitment of this kinase into the enzyme scaffold. We also find that AKAP220 anchors GSK3beta and its substrate beta-catenin in membrane ruffles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKAP11 | up-regulates quantity 
binding
|
PKA |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273741 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21776420 |
We show that IQGAP2 is regulated by an interaction with the A-kinase anchoring protein AKAP220. Phosphorylation of IQGAP2 via AKAP220-anchored PKA leads to enhanced Rac binding. Since AKAPs function to direct PKA toward specific substrates, we proposed that the formation of an IQGAP2/AKAP220/PKA ternary complex sharpens the response to cAMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKAP11 | down-regulates activity
binding
|
GSK3B |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264817 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26088133 |
A-kinase anchoring protein 220 (AKAP220) is a multivalent anchoring protein that can sequester a variety of signal transduction enzymes. These include protein kinase A (PKA) and glycogen synthase kinase 3beta (GSK3beta). Using a combination of molecular and cellular approaches we show that GSK3beta phosphorylation of Thr-1132 on AKAP220 initiates recruitment of this kinase into the enzyme scaffold. We also find that AKAP220 anchors GSK3beta and its substrate beta-catenin in membrane ruffles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKAP11 | up-regulates activity
binding
|
IQGAP2 |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273740 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21776420 |
We show that IQGAP2 is regulated by an interaction with the A-kinase anchoring protein AKAP220. Phosphorylation of IQGAP2 via AKAP220-anchored PKA leads to enhanced Rac binding. Since AKAPs function to direct PKA toward specific substrates, we proposed that the formation of an IQGAP2/AKAP220/PKA ternary complex sharpens the response to cAMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKAP11 | down-regulates activity
binding
|
PKA |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264818 |
|
|
|
|
| pmid |
sentence |
| 26088133 |
A-kinase anchoring protein 220 (AKAP220) is a multivalent anchoring protein that can sequester a variety of signal transduction enzymes. These include protein kinase A (PKA) and glycogen synthase kinase 3beta (GSK3beta). |
|
| Publications: |
1 |
3.0
AKAP11
- 
- 