4.0
Summary
| Name |  PTBP2
|
| Full Name | Polypyrimidine tract-binding protein 2 |
| Synonyms | Neural polypyrimidine tract-binding protein, Neurally-enriched homolog of PTB, PTB-like protein | NPTB, PTB, PTBLP |
| Primary ID | Q9UKA9 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PTBP2 | up-regulates activity 
binding
|
KHSRP | 0.466 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTBP2 | up-regulates activity
binding
|
HNRNPH1 | 0.393 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTBP2 | down-regulates quantity by repression 
post transcriptional regulation
|
SRC | 0.287 |
| Publications: | 1 | Organism: | Homo Sapiens | |