4.0
Summary
| Name |  FBXO5View Modifications |
| Full Name | F-box only protein 5 |
| Synonyms | Early mitotic inhibitor 1 | EMI1, FBX5 |
| Primary ID | Q9UKT4 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:29875408, PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase (PubMed:29875408). Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment (PubMed:29875408). As APC inhibitor, prevents the degradation of APC substrates at multiple levels |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SRC | up-regulates 
phosphorylation
|
FBXO5 | 0.324 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXO5 | down-regulates 
ubiquitination
|
FZR1 | 0.756 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PLK1 | down-regulates
phosphorylation
|
FBXO5 | 0.783 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | CDK1 | down-regulates quantity by destabilization
phosphorylation
|
FBXO5 | 0.753 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXO5 | down-regulates
binding
|
ANAPC7 | 0.458 |
| Publications: | 1 | Organism: | Homo Sapiens | |