3.0
Summary
| Name |  FBXO4View Modifications |
| Full Name | F-box only protein 4 |
| Synonyms | FBX4_HUMAN | FBX4 |
| Primary ID | Q9UKT5 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GSK3B | up-regulates 
phosphorylation
|
FBXO4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXO4 | up-regulates
binding
|
Cullin 1-RBX1-Skp1 | 0.613 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXO4 | down-regulates quantity by destabilization 
binding
|
FXR1 | 0.468 |
| Publications: | 1 | Organism: | Homo Sapiens | |