Summary

Name KIDINS220
Full Name Kinase D-interacting substrate of 220 kDa
Synonyms Ankyrin repeat-rich membrane-spanning protein | ARMS, KIAA1250
Primary ID Q9ULH0
Links - -
Type protein
Relations 1
Function Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation KIDINS220 0.539
Publications: 1 Organism: Rattus Norvegicus