3.0
Summary
| Name |  KIDINS220View Modifications |
| Full Name | Kinase D-interacting substrate of 220 kDa |
| Synonyms | Ankyrin repeat-rich membrane-spanning protein | ARMS, KIAA1250 |
| Primary ID | Q9ULH0 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. |
phosphorylation