Summary

Name CADPS
Full Name Calcium-dependent secretion activator 1
Synonyms Calcium-dependent activator protein for secretion 1, CAPS-1 | CAPS, CAPS1, KIAA1121
Primary ID Q9ULU8
Links - -
Type protein
Relations 4
Function Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ CADPSup-regulates activity img/direct-activation.png binding STX1A 0.415
Publications: 1 Organism: Homo Sapiens
+ phosphatidylinositol bisphosphateup-regulates activity img/direct-activation.png chemical activation CADPS 0.8
Publications: 1 Organism: Homo Sapiens
+ CADPSup-regulates activity img/direct-activation.png binding VAMP2 0.445
Publications: 1 Organism: Homo Sapiens
+ CADPSup-regulates activity img/direct-activation.png binding SNAP25 0.381
Publications: 1 Organism: Homo Sapiens