Summary

Name PADI4
Full Name Protein-arginine deiminase type-4
Synonyms HL-60 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type IV | PAD4, PADI5, PDI5
Primary ID Q9UM07
Links - -
Type protein
Relations 1
Function Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci) (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1

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Relations

Regulator Mechanism target score ℹ
+ SMURF1 img/unknown.png ubiquitination PADI4 0.2
Publications: 1 Organism: In Vitro