| + |
CDK1 | down-regulates quantity by destabilization 
phosphorylation
|
USP24 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275605 |
Ser1616 |
NSHSPAGsAAISQQD |
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 27991932 |
Epidermal growth factor (EGF) treatment, and the KrasG12D and EGFRL858R mutations decrease USP24 protein stability via EGF- or CDK1-mediated phosphorylation at Ser1616, Ser2047 and Ser2604. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275604 |
Ser2047 |
QRVSDQNsPVLPKKS |
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 27991932 |
Epidermal growth factor (EGF) treatment, and the KrasG12D and EGFRL858R mutations decrease USP24 protein stability via EGF- or CDK1-mediated phosphorylation at Ser1616, Ser2047 and Ser2604. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275603 |
Ser2604 |
HLQQGSEsPMMIGEL |
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 27991932 |
Epidermal growth factor (EGF) treatment, and the KrasG12D and EGFRL858R mutations decrease USP24 protein stability via EGF- or CDK1-mediated phosphorylation at Ser1616, Ser2047 and Ser2604. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CyclinB/CDK1 | down-regulates quantity by destabilization
phosphorylation
|
USP24 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275611 |
Ser1616 |
NSHSPAGsAAISQQD |
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 27991932 |
Epidermal growth factor (EGF) treatment, and the KrasG12D and EGFRL858R mutations decrease USP24 protein stability via EGF- or CDK1-mediated phosphorylation at Ser1616, Ser2047 and Ser2604. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275610 |
Ser2047 |
QRVSDQNsPVLPKKS |
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 27991932 |
Epidermal growth factor (EGF) treatment, and the KrasG12D and EGFRL858R mutations decrease USP24 protein stability via EGF- or CDK1-mediated phosphorylation at Ser1616, Ser2047 and Ser2604. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275609 |
Ser2604 |
HLQQGSEsPMMIGEL |
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 27991932 |
Epidermal growth factor (EGF) treatment, and the KrasG12D and EGFRL858R mutations decrease USP24 protein stability via EGF- or CDK1-mediated phosphorylation at Ser1616, Ser2047 and Ser2604. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
ATM | up-regulates activity 
phosphorylation
|
USP24 |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280043 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25578727 |
Taken together, these data suggest that the ATM kinase mediated phosphorylation of USP24 is involved in USP24 stabilization/up regulation following UV irradiation.|Taken together, these data suggest that the ATM kinase-mediated phosphorylation of USP24 is involved in USP24 stabilization/up-regulation following UV irradiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP24 | up-regulates
deubiquitination
|
DDB2 |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199731 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23159851 |
Usp24-mediated ddb2 deubiquitination prevents ddb2 degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP24 | up-regulates quantity by stabilization
deubiquitination
|
BAX |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275606 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 27991932 |
In this study, several cancer-related proteins (Bax, p300, E2F4 and securin) have been proven to be substrates of ubiquitin-specific peptidase 24 (USP24), and relevance has been shown between USP24 and its substrates in samples from clinical lung cancer patients. |Knockdown of USP24 decreases Bax and p300 levels |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP24 | up-regulates quantity by stabilization
deubiquitination
|
EP300 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275607 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 27991932 |
In this study, several cancer-related proteins (Bax, p300, E2F4 and securin) have been proven to be substrates of ubiquitin-specific peptidase 24 (USP24), and relevance has been shown between USP24 and its substrates in samples from clinical lung cancer patients. |Knockdown of USP24 decreases Bax and p300 levels |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
USP24
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- 