3.0
Summary
| Name |  EXO1
|
| Full Name | Exonuclease 1 |
| Synonyms | hExo1, Exonuclease I, hExoI | EXOI, HEX1 |
| Primary ID | Q9UQ84 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. |
phosphorylation