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Summary
Name
ANGPT4
Full Name
Angiopoietin-4
Synonyms
ANG-4, Angiopoietin-3, ANG-3 | ANG3, ANG4
Primary ID
Q9Y264
Links
-
-
Type
protein
Relations
1
Function
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
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by mechanism
none
binding
by effect
none
up-regulates
by organism:
none
Homo sapiens
by tissue:
none
lung
by cell-line
none
uveal melanoma cell
Relations
Regulator
Mechanism
target
score
ℹ
+
ANGPT4
up-regulates
binding
TEK
0.688
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-127351
Homo sapiens
Uveal Melanoma Cell
pmid
sentence
15284220
In experiments with human endothelial cell lines, ang3 was identified as an antagonist of tie2 and ang4 was identified as an agonist of tie2.
Publications:
1
Organism:
Homo Sapiens
Tissue:
Lung