| + |
PLK1 | up-regulates activity 
phosphorylation
|
NUDC |
0.719 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103403 |
Ser274 |
KKINPENsKLSDLDS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12852857 |
Here, we characterize the interaction between plk1 and nudc, show that plk1 phosphorylates nudc at conserved s274 and s326 residues in vitro, and present evidence that nudc is also a substrate for plk1 in vivo. Downregulation of nudc by rna interference results in multiple mitotic defects, including multinucleation and cells arrested at the midbody stage, which are rescued by ectopic expression of wild-type nudc, but not by nudc with mutations in the plk1 phosphorylation sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103407 |
Ser326 |
QHPEMDFsKAKFN |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12852857 |
Here, we characterize the interaction between plk1 and nudc, show that plk1 phosphorylates nudc at conserved s274 and s326 residues in vitro, and present evidence that nudc is also a substrate for plk1 in vivo. Downregulation of nudc by rna interference results in multiple mitotic defects, including multinucleation and cells arrested at the midbody stage, which are rescued by ectopic expression of wild-type nudc, but not by nudc with mutations in the plk1 phosphorylation sites. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
NUDC
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