Summary

Name INVS
Full Name Inversin
Synonyms Inversion of embryo turning homolog, Nephrocystin-2 | INV, NPHP2
Primary ID Q9Y283
Links - -
Type protein
Relations 1
Function Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png ubiquitination DVL1 0.632
Publications: 1 Organism: Homo Sapiens