4.0
Summary
| Name |  HIF3AView Modifications |
| Full Name | Hypoxia-inducible factor 3-alpha |
| Synonyms | HIF-3-alpha, HIF3-alpha, Basic-helix-loop-helix-PAS protein MOP7, Class E basic helix-loop-helix protein 17, bHLHe17, HIF3-alpha-1, Inhibitory PAS domain protein, IPAS, Member of PAS protein 7, PAS domain-containing protein 7 | BHLHE17, MOP7, PASD7 |
| Primary ID | Q9Y2N7 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PINK1 | down-regulates activity 
phosphorylation
|
HIF3A | 0.349 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HIF3A | down-regulates quantity by repression
transcriptional regulation
|
EPAS1 | 0.528 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKN | down-regulates quantity by destabilization
ubiquitination
|
HIF3A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HIF3A | down-regulates quantity by repression
transcriptional regulation
|
HIF1A | 0.522 |
| Publications: | 1 | Organism: | Homo Sapiens | |