| Name
|
 LAMTOR2
|
| Full Name |
Ragulator complex protein LAMTOR2 |
| Synonyms |
Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding protein-interacting protein, MAPBP-interacting protein, Roadblock domain-containing protein 3 | MAPBPIP, ROBLD3 |
| Primary ID |
Q9Y2Q5 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. |
3.0
binding