| + |
LAMTOR1 | form complex 
binding
|
LAMTOR |
0.921 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164769 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20381137 |
Mammals express four rag proteinsRaga, ragb, ragc, and ragdthat form heterodimers consisting of raga or ragb with ragc or ragd. Raga and ragb, like ragc and ragd, are highly similar to each other and are functionally redundant |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LAMTOR2 | form complex
binding
|
LAMTOR |
0.922 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164772 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20381137 |
Mammals express four rag proteinsRaga, ragb, ragc, and ragdthat form heterodimers consisting of raga or ragb with ragc or ragd. Raga and ragb, like ragc and ragd, are highly similar to each other and are functionally redundant |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LAMTOR4 | form complex
binding
|
LAMTOR |
0.921 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164778 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20381137 |
Mammals express four rag proteinsRaga, ragb, ragc, and ragdthat form heterodimers consisting of raga or ragb with ragc or ragd. Raga and ragb, like ragc and ragd, are highly similar to each other and are functionally redundant |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LAMTOR5 | form complex
binding
|
LAMTOR |
0.892 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164781 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20381137 |
Mammals express four rag proteinsRaga, ragb, ragc, and ragdthat form heterodimers consisting of raga or ragb with ragc or ragd. Raga and ragb, like ragc and ragd, are highly similar to each other and are functionally redundant |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LAMTOR3 | form complex
binding
|
LAMTOR |
0.927 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164775 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20381137 |
Mammals express four rag proteinsRaga, ragb, ragc, and ragdthat form heterodimers consisting of raga or ragb with ragc or ragd. Raga and ragb, like ragc and ragd, are highly similar to each other and are functionally redundant |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AminoAcids | up-regulates 
|
LAMTOR |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228152 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20381137 |
The trimeric Ragulator complex, which comprises the p18, p14, and MP1 proteins, anchors the Rag GTPases to the lysosome, and, like the Rags, is necessary for mTORC1 activation by amino acids |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mTOR in cancer, MTOR Signaling |
| + |
LAMTOR | up-regulates activity 
relocalization
|
RAGAC |
0.871 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228155 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20381137 |
We identify the trimeric Ragulator protein complex as a new component of the mTORC1 pathway that interacts with the Rag GTPases, is essential for localizing them and mTORC1 to the lysosomal surface, and is necessary for the activation of the mTORC1 pathway by amino acids. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mTOR in cancer, MTOR Signaling |
3.0
LAMTOR
CPX-4741