Relation Results

Name	GPR52
Full Name	G protein-coupled receptor 52
Synonyms	\|
Primary ID	Q9Y2T5
Links	- -
Type	protein
Relations	5
Function	Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). {ECO:0000269\|PubMed:24587241, ECO:0000269\|PubMed:25738228}.