4.0
Summary
| Name |  MAP3K2View Modifications |
| Full Name | Mitogen-activated protein kinase kinase kinase 2 |
| Synonyms | MAPK/ERK kinase kinase 2, MEK kinase 2, MEKK 2 | MAPKKK2, MEKK2 |
| Primary ID | Q9Y2U5 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAP3K2 | up-regulates quantity by stabilization 
phosphorylation
|
STK38 | 0.404 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP3K2 | up-regulates activity
phosphorylation
|
MAP2K4 | 0.61 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP3K2 | up-regulates
phosphorylation
|
MAP2K1 | 0.416 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP3K2 | down-regulates quantity 
phosphorylation
|
PXN | 0.362 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP3K2 | up-regulates activity
phosphorylation
|
MAP2K7 | 0.602 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP3K2 | up-regulates 
|
MAP2K5 | 0.763 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP3K2 | up-regulates
phosphorylation
|
MEK1/2 | 0.416 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP3K2 | up-regulates
phosphorylation
|
MAP2K5 | 0.763 |
| Publications: | 1 | Organism: | Homo Sapiens | |