3.0
Summary
| Name |  NOSIP
|
| Full Name | Nitric oxide synthase-interacting protein |
| Synonyms | E3 ubiquitin-protein ligase NOSIP, EC 2.3.2.27, RING-type E3 ubiquitin transferase NOSIP, eNOS-interacting protein | |
| Primary ID | Q9Y314 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. |
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ubiquitination
ubiquitination