Relation Results

Summary

Name RNF11
Full Name RING finger protein 11
Synonyms RNF11_HUMAN
Primary ID Q9Y3C5
Links - -
Type protein
Relations 6
Pathways NF-KB Canonical
Function Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammato ...
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Type: Score: Layout: SPV 
0.20.4640.5510.20.5410.564AKTRNF11AKT1SMURF2Ub:E2STAMBPITCH

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ AKTdown-regulates quantity img/direct_inhibition.png phosphorylation RNF11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-248085 Thr135 DWLMRSFtCPSCMEP Homo sapiens WM-239 Cell
pmid sentence
Upon inhibition of the AKT pathway or mutation of T135, the phosphorylation at one of these sites is virtually eliminated, suggesting that AKT may phosphorylate RNF11 at T135. Moreover, RNF11 is phosphorylated by AKT in vitro and is recognized by phospho-AKT substrate antibodies. RNF11 shows enhanced binding to 14-3-3 in WM239 cells compared with that seen in the parental WM35 cells which have low AKT activity
Publications: 1 Organism: Homo Sapiens
+ AKT1down-regulates quantity img/direct_inhibition.png phosphorylation RNF11 0.464
Identifier Residue Sequence Organism Cell Line
SIGNOR-252558 Thr135 DWLMRSFtCPSCMEP Homo sapiens WM-239 Cell
pmid sentence
Upon inhibition of the AKT pathway or mutation of T135, the phosphorylation at one of these sites is virtually eliminated, suggesting that AKT may phosphorylate RNF11 at T135. Moreover, RNF11 is phosphorylated by AKT in vitro and is recognized by phospho-AKT substrate antibodies. RNF11 shows enhanced binding to 14-3-3 in WM239 cells compared with that seen in the parental WM35 cells which have low AKT activity
Publications: 1 Organism: Homo Sapiens
+ RNF11up-regulates activity img/direct-activation.png binding SMURF2 0.551
Identifier Residue Sequence Organism Cell Line
SIGNOR-272952 Homo sapiens HEK-293 Cell
pmid sentence
RNF11 recruits AMSH to Smurf2 E3 ligase. Smurf2 promotes ubiquitination of AMSH in the presence of wt RNF11. Previously, we have shown that RNF11 interacts with the HECT-type E3 ligases AIP4 and Smurf2. Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif. Our results also demonstrate that AMSH is ubiquitinated by Smurf2 E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and Smurf2. RNF11 therefore recruits AMSH to Smurf2 for ubiquitination, leading to its degradation by the 26S proteasome.
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RNF11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271038 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
+ RNF11down-regulates quantity by destabilization img/direct_inhibition.png binding STAMBP 0.541
Identifier Residue Sequence Organism Cell Line
SIGNOR-272953 Homo sapiens HEK-293 Cell
pmid sentence
RNF11 recruits AMSH to Smurf2 E3 ligase. Smurf2 promotes ubiquitination of AMSH in the presence of wt RNF11. Previously, we have shown that RNF11 interacts with the HECT-type E3 ligases AIP4 and Smurf2. Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-finger domain and the PY motif. Our results also demonstrate that AMSH is ubiquitinated by Smurf2 E3 ligase in the presence of RNF11 and that a consequent reduction in its steady-state level requires both RNF11 and Smurf2. RNF11 therefore recruits AMSH to Smurf2 for ubiquitination, leading to its degradation by the 26S proteasome.
Publications: 1 Organism: Homo Sapiens
+ RNF11up-regulates activity img/direct-activation.png binding ITCH 0.564
Identifier Residue Sequence Organism Cell Line
SIGNOR-183188 Homo sapiens Breast Cancer Cell
pmid sentence
Rnf11, together with tax1bp1 and itch, is an essential component of an a20 ubiquitin-editing protein complex; rnf11 is required for a20 to interact with and inactivate rip1 to inhibit tnf-mediated nf-_kb activation.
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , NF-KB Canonical
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