IL1 Signaling

Pathway ID: SIGNOR-IL1RView in NDEx

Description: Interleukin-1 (IL-1) is a proinflammatory cytokine produced by activated macrophages, endothelial cells, B cells and fibroblasts. IL-1 play a central role in inflammation and host defence against infection. The signalling pathways involve two adapter proteins, MyD88 and Tollip, which via two IL-1 receptor-associated kinases (IRAK and IRAK-2) activate transcription factors such as nuclear factor-kappa B.

Curated by: Elena Santonico

18 Seed Entities

Organism:
Name Primary ID
IL1RAP Q9NPH3
NfKb-p65/p50 SIGNOR-C13
BIRC3 Q13489
MYD88 Q99836
IRAK1 P51617
TRAF6 Q9Y4K3
Inflammation SIGNOR-PH12
MAP3K7 O43318
NFKBIA P25963
TOLLIP Q9H0E2
IL1R1 P14778
TAB2 Q9NYJ8
IL1RN P18510
PELI1 Q96FA3
IKK-complex SIGNOR-C14
IL1B P01584
IL1A P01583
IRAK4 Q9NWZ3