Relation Results

Summary

Name FBXO7
Full Name F-box only protein 7
Synonyms | FBX7
Primary ID Q9Y3I1
Links - -
Type protein
Relations 5
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequen ...
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Type: Score: Layout: SPV 
0.650.6090.4530.20.257FBXO7Cullin 1-RBX1-Skp1SCF-FBW7DLGAP5WDR62CRBN

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Relations
Regulator
Mechanism
target
score ℹ
+ FBXO7up-regulates activity img/direct-activation.png binding Cullin 1-RBX1-Skp1 0.65
Identifier Residue Sequence Organism Cell Line
SIGNOR-272315 Homo sapiens MM-1 Cell
pmid sentence
We have shown that CRBN is also targeted for degradation by SCFFbxo7 ubiquitin ligase. 
Publications: 1 Organism: Homo Sapiens
+ FBXO7up-regulates activity img/direct-activation.png binding SCF-FBW7 0.609
Identifier Residue Sequence Organism Cell Line
SIGNOR-271507 Homo sapiens HEK-293 Cell
pmid sentence
We show here that Fbx7, an F-box protein without WD repeats and leucine-rich repeats, is required for the proteasome-mediated proteolysis of the hepatoma up-regulated protein (HURP).Thus, Fbx7 is a functional adaptor of the SCF complex with a proline-rich region as the substrate-binding module. Depletion of Fbx7 by small interfering RNA leads to depression of HURP ubiquitination and accumulation of HURP abundance. In the SCFFbx7 complex, Fbx7 recruits HURP through its C-terminal proline-rich region in a Cdk1-cyclin B-phosphorylation dependent manner.
Publications: 1 Organism: Homo Sapiens
+ FBXO7down-regulates quantity by destabilization img/direct_inhibition.png binding DLGAP5 0.453
Identifier Residue Sequence Organism Cell Line
SIGNOR-271506 Homo sapiens HEK-293 Cell
pmid sentence
We show here that Fbx7, an F-box protein without WD repeats and leucine-rich repeats, is required for the proteasome-mediated proteolysis of the hepatoma up-regulated protein (HURP).Thus, Fbx7 is a functional adaptor of the SCF complex with a proline-rich region as the substrate-binding module. Depletion of Fbx7 by small interfering RNA leads to depression of HURP ubiquitination and accumulation of HURP abundance. In the SCFFbx7 complex, Fbx7 recruits HURP through its C-terminal proline-rich region in a Cdk1-cyclin B-phosphorylation dependent manner.
Publications: 1 Organism: Homo Sapiens
+ FBXO7down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination WDR62 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271711 Homo sapiens HEK-293 Cell
pmid sentence
WDR62 is also negatively regulated by T1053 phosphorylation, leading to the recruitment of F-box and WD repeat domain-containing protein 7 (FBW7) and proteasomal degradation. |JNK1 can induce the phosphorylation of WDR62 T1053
Publications: 1 Organism: Homo Sapiens
+ FBXO7down-regulates quantity by destabilization img/direct_inhibition.png binding CRBN 0.257
Identifier Residue Sequence Organism Cell Line
SIGNOR-272311 Homo sapiens MM-1 Cell
pmid sentence
We have shown that CRBN is also targeted for degradation by SCFFbxo7 ubiquitin ligase. 
Publications: 1 Organism: Homo Sapiens
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