| + |
FBXO7 | down-regulates quantity by destabilization 
binding
|
CRBN |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272311 |
|
|
Homo sapiens |
MM-1 Cell |
| pmid |
sentence |
| 30026574 |
We have shown that CRBN is also targeted for degradation by SCFFbxo7 ubiquitin ligase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO7 | up-regulates activity 
binding
|
Cullin 1-RBX1-Skp1 |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272315 |
|
|
Homo sapiens |
MM-1 Cell |
| pmid |
sentence |
| 30026574 |
We have shown that CRBN is also targeted for degradation by SCFFbxo7 ubiquitin ligase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO7 | up-regulates activity
binding
|
SCF-FBW7 |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271507 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15145941 |
We show here that Fbx7, an F-box protein without WD repeats and leucine-rich repeats, is required for the proteasome-mediated proteolysis of the hepatoma up-regulated protein (HURP).Thus, Fbx7 is a functional adaptor of the SCF complex with a proline-rich region as the substrate-binding module. Depletion of Fbx7 by small interfering RNA leads to depression of HURP ubiquitination and accumulation of HURP abundance. In the SCFFbx7 complex, Fbx7 recruits HURP through its C-terminal proline-rich region in a Cdk1-cyclin B-phosphorylation dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO7 | down-regulates quantity by destabilization
ubiquitination
|
WDR62 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271711 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 30566428 |
WDR62 is also negatively regulated by T1053 phosphorylation, leading to the recruitment of F-box and WD repeat domain-containing protein 7 (FBW7) and proteasomal degradation. |JNK1 can induce the phosphorylation of WDR62 T1053 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO7 | down-regulates quantity by destabilization
binding
|
DLGAP5 |
0.462 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271506 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15145941 |
We show here that Fbx7, an F-box protein without WD repeats and leucine-rich repeats, is required for the proteasome-mediated proteolysis of the hepatoma up-regulated protein (HURP).Thus, Fbx7 is a functional adaptor of the SCF complex with a proline-rich region as the substrate-binding module. Depletion of Fbx7 by small interfering RNA leads to depression of HURP ubiquitination and accumulation of HURP abundance. In the SCFFbx7 complex, Fbx7 recruits HURP through its C-terminal proline-rich region in a Cdk1-cyclin B-phosphorylation dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FBXO7
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