Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-116577 |
|
|
Homo sapiens |
B-lymphocyte |
pmid |
sentence |
11955446 |
Here we report the identification of two segment polarity genes in drosophila, legless (lgs), and pygopus (pygo), and we show that their products are required for wnt signal transduction at the level of nuclear beta-catenin. Lgs encodes the homolog of human bcl9, and we provide genetic and molecular evidence that these proteins exert their function by physically linking pygo to beta-catenin. |
|