Summary

Name KNSTRN
Full Name Small kinetochore-associated protein
Synonyms SKAP, Kinetochore-localized astrin-binding protein, Kinastrin, Kinetochore-localized astrin/SPAG5-binding protein, TRAF4-associated factor 1 | C15orf23, SKAP, TRAF4AF1
Primary ID Q9Y448
Links - -
Type protein
Relations 2
Function Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png relocalization KIF2B 0.424
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KNSTRN 0.265
Publications: 1 Organism: Homo Sapiens