Relation Results

Summary

Name KNSTRN
Full Name Small kinetochore-associated protein
Synonyms SKAP, Kinetochore-localized astrin-binding protein, Kinastrin, Kinetochore-localized astrin/SPAG5-binding protein, TRAF4-associated factor 1 | C15orf23, SKAP, TRAF4AF1
Primary ID Q9Y448
Links - -
Type protein
Relations 2
Function Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the ...
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Type: Score: Layout: SPV 
0.2610.41AURKAKNSTRNKIF2B

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Relations
Regulator
Mechanism
target
score ℹ
+ AURKAdown-regulates activity img/direct_inhibition.png phosphorylation KNSTRN 0.261
Identifier Residue Sequence Organism Cell Line
SIGNOR-252052 Homo sapiens U2-OS Cell
pmid sentence
The protein astrin has been shown to remove Kif2b from kinetochores in metaphase through competitive binding of CLASP1 (Manning et al., 2010 blue right-pointing triangle). During prometaphase, Aurora B kinase activity prevents astrin from localizing to kinetochores (Manning et al., 2010 blue right-pointing triangle; Schmidt et al., 2010 blue right-pointing triangle). This permits Kif2b to localize to kinetochores to destabilize k-MT attachments to execute error correction through Plk1-dependent recruitment and activation.
Publications: 1 Organism: Homo Sapiens
+ KNSTRNdown-regulates activity img/direct_inhibition.png relocalization KIF2B 0.41
Identifier Residue Sequence Organism Cell Line
SIGNOR-252053 Homo sapiens U2-OS Cell
pmid sentence
The protein astrin has been shown to remove Kif2b from kinetochores in metaphase through competitive binding of CLASP1 (Manning et al., 2010 blue right-pointing triangle). During prometaphase, Aurora B kinase activity prevents astrin from localizing to kinetochores (Manning et al., 2010 blue right-pointing triangle; Schmidt et al., 2010 blue right-pointing triangle). This permits Kif2b to localize to kinetochores to destabilize k-MT attachments to execute error correction through Plk1-dependent recruitment and activation.
Publications: 1 Organism: Homo Sapiens
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