Relation Results

Summary

Name NRXN3
Full Name Neurexin-3
Synonyms Neurexin III-alpha, Neurexin-3-alpha | C14orf60, KIAA0743
Primary ID Q9Y4C0
Links - -
Type protein
Relations 9
Function Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

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Type: Score: Layout: SPV 
0.8260.3770.20.8290.8250.7680.3020.20.825NLGN3NRXN3NXPH1NLGN4YNLGN1NLGN2NLGN4XDGCDAG1

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Relations
Regulator
Mechanism
target
score ℹ
+ NLGN3up-regulates activity img/direct-activation.png binding NRXN3 0.826
Identifier Residue Sequence Organism Cell Line
SIGNOR-264162 Homo sapiens Neuron
pmid sentence
Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements and mediate trans-synaptic signaling.|Nlgns bind to both alpha- and beta-Nrxns with nanomolar affinities; binding involves the sixth LNS-domain of alpha-Nrxns which corresponds to the only LNS-domain of beta-Nrxns52. The binding affinities differ characteristically between various pairs of Nlgns and Nrxns, and are controlled by alternative splicing of both Nrxns and Nlgns (Figure 1c)
Publications: 1 Organism: Homo Sapiens
+ NXPH1up-regulates img/direct-activation.png binding NRXN3 0.377
Identifier Residue Sequence Organism Cell Line
SIGNOR-60643 Homo sapiens Neuron
pmid sentence
We show that neurexophilins 1 and 3 but not 4 (neurexophilin 2 is not expressed in rodents) bind to a single individual lns domain, the second overall lns domain in all three alpha-neurexins.
Publications: 1 Organism: Homo Sapiens
+ NLGN4Yup-regulates activity img/direct-activation.png binding NRXN3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264163 Homo sapiens Neuron
pmid sentence
Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements and mediate trans-synaptic signaling.|Nlgns bind to both alpha- and beta-Nrxns with nanomolar affinities; binding involves the sixth LNS-domain of alpha-Nrxns which corresponds to the only LNS-domain of beta-Nrxns52. The binding affinities differ characteristically between various pairs of Nlgns and Nrxns, and are controlled by alternative splicing of both Nrxns and Nlgns (Figure 1c)
Publications: 1 Organism: Homo Sapiens
+ NLGN1up-regulates activity img/direct-activation.png binding NRXN3 0.829
Identifier Residue Sequence Organism Cell Line
SIGNOR-264164 Homo sapiens Neuron
pmid sentence
Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements and mediate trans-synaptic signaling.|Nlgns bind to both alpha- and beta-Nrxns with nanomolar affinities; binding involves the sixth LNS-domain of alpha-Nrxns which corresponds to the only LNS-domain of beta-Nrxns52. The binding affinities differ characteristically between various pairs of Nlgns and Nrxns, and are controlled by alternative splicing of both Nrxns and Nlgns (Figure 1c)
Publications: 1 Organism: Homo Sapiens
+ NLGN2up-regulates activity img/direct-activation.png binding NRXN3 0.825
Identifier Residue Sequence Organism Cell Line
SIGNOR-264166 Homo sapiens Neuron
pmid sentence
Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements and mediate trans-synaptic signaling.|Nlgns bind to both alpha- and beta-Nrxns with nanomolar affinities; binding involves the sixth LNS-domain of alpha-Nrxns which corresponds to the only LNS-domain of beta-Nrxns52. The binding affinities differ characteristically between various pairs of Nlgns and Nrxns, and are controlled by alternative splicing of both Nrxns and Nlgns (Figure 1c)
Publications: 1 Organism: Homo Sapiens
+ NLGN4Xup-regulates activity img/direct-activation.png binding NRXN3 0.768
Identifier Residue Sequence Organism Cell Line
SIGNOR-264165 Homo sapiens Neuron
pmid sentence
Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements and mediate trans-synaptic signaling.|Nlgns bind to both alpha- and beta-Nrxns with nanomolar affinities; binding involves the sixth LNS-domain of alpha-Nrxns which corresponds to the only LNS-domain of beta-Nrxns52. The binding affinities differ characteristically between various pairs of Nlgns and Nrxns, and are controlled by alternative splicing of both Nrxns and Nlgns (Figure 1c)
Publications: 1 Organism: Homo Sapiens
+ DGCup-regulates activity img/direct-activation.png binding NRXN3 0.302
Identifier Residue Sequence Organism Cell Line
SIGNOR-265451 Homo sapiens
pmid sentence
In brain, dystroglycan and dystrophin are expressed on neurons and astrocytes, and some muscular dystrophies cause cognitive dysfunction. Our data indicate that dystroglycan is a physiological ligand for neurexins and that neurexins' tightly regulated interaction could mediate cell adhesion between brain cells. these results suggest that α- and β-neurexins represent ligands for dystroglycan via interactions of their LNS domains, analogous to interaction of the LNS-domain in laminin, agrin, and perlecan with dystroglycan.
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ NRXN3up-regulates activity img/direct-activation.png binding DAG1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265463 Homo sapiens
pmid sentence
The DGC is potentially recruited to the postsynaptic membrane though a direct neurexin–dystroglycan interaction and an indirect interaction with NL2 via the synaptic scaffolding protein S-SCAM.
Publications: 1 Organism: Homo Sapiens
+ NRXN3up-regulates activity img/direct-activation.png binding NLGN2 0.825
Identifier Residue Sequence Organism Cell Line
SIGNOR-265457 Homo sapiens
pmid sentence
The neurexin–NL2 interaction is sufficient to induce GABAergic differentiation and clustering of GABAARs at postsynaptic sites
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
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