| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265467 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22190735 |
LAS1L was first described as a nucleolar protein required for maturation of the 60S preribosomal subunit. In this paper, we demonstrate that LAS1L interacts with PELP1, TEX10, and WDR18, the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 and SENP3, to form a novel nucleolar complex that cofractionates with the 60S preribosomal subunit. our data identify a novel mammalian complex required for 60S ribosomal subunit synthesis, providing further insight into the intricate, yet poorly described, process of ribosome biogenesis in higher eukaryotes. |
|
3.0
LAS1L
- 
- 
binding