4.0
Summary
| Name |  AP4S1
|
| Full Name | AP-4 complex subunit sigma-1 |
| Synonyms | AP-4 adaptor complex subunit sigma-1, Adaptor-related protein complex 4 subunit sigma-1, Sigma-1 subunit of AP-4, Sigma-4-adaptin, Sigma4-adaptin | |
| Primary ID | Q9Y587 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AP4S1 | form complex 
binding
|
AP-4 Adaptor complex | 0.862 |
| Publications: | 1 | Organism: | Homo Sapiens | |