| + |
CTDP1 | down-regulates activity 
dephosphorylation
|
MASTL |
0.446 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276971 |
Ser453 |
NFELVDSsPCKKIIQ |
Homo sapiens |
|
| pmid |
sentence |
| 26653855 |
Taken together, these data suggest that Fcp1 bound and dephosphorylated Gwl at S90 and S453, and possibly at other Cdk1 dependent sites, during mitosis exit and that Fcp1 catalyzed dephosphorylation lowered Gwl activity towards Ensa and ARPP19, allowing PP2A-B55 to autoactivate.|Together, these data indicate that Fcp1 dependent dephosphorylation greatly reduces S67-Ensa kinase activity of Gwl and that, downstream inactivation of Cdk1, Fcp1 deficit substantially blunts inactivation of Gwl. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276972 |
Ser90 |
DALALSKsPFIVHLY |
Homo sapiens |
|
| pmid |
sentence |
| 26653855 |
Taken together, these data suggest that Fcp1 bound and dephosphorylated Gwl at S90 and S453, and possibly at other Cdk1 dependent sites, during mitosis exit and that Fcp1 catalyzed dephosphorylation lowered Gwl activity towards Ensa and ARPP19, allowing PP2A-B55 to autoactivate.|Together, these data indicate that Fcp1 dependent dephosphorylation greatly reduces S67-Ensa kinase activity of Gwl and that, downstream inactivation of Cdk1, Fcp1 deficit substantially blunts inactivation of Gwl. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK2A2 | down-regulates activity
phosphorylation
|
CTDP1 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250985 |
Ser575 |
AGESLDQsMEEEEEE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12591939 |
We found that only phosphorylated FCP1 can physically interact with TFIIF. We set out to purify an FCP1 kinase from HeLa cells and identified casein kinase 2, which, surprisingly, displayed a negative effect on FCP1-associated activities.| Phosphorylation of FCP1 by CK2 Inhibits the Transcription Elongation Activity of FCP1. | Two in vivo phosphorylation sites within the C terminus of FCP1 at Ser-575 and Ser-740 were identified |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250986 |
Ser740 |
TKAQRENsPAAFPDR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12591939 |
We found that only phosphorylated FCP1 can physically interact with TFIIF. We set out to purify an FCP1 kinase from HeLa cells and identified casein kinase 2, which, surprisingly, displayed a negative effect on FCP1-associated activities.| Phosphorylation of FCP1 by CK2 Inhibits the Transcription Elongation Activity of FCP1. | Two in vivo phosphorylation sites within the C terminus of FCP1 at Ser-575 and Ser-740 were identified |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 | down-regulates activity
phosphorylation
|
CTDP1 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250844 |
Ser575 |
AGESLDQsMEEEEEE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12591939 |
We found that only phosphorylated FCP1 can physically interact with TFIIF. We set out to purify an FCP1 kinase from HeLa cells and identified casein kinase 2, which, surprisingly, displayed a negative effect on FCP1-associated activities.| Phosphorylation of FCP1 by CK2 Inhibits the Transcription Elongation Activity of FCP1. | Two in vivo phosphorylation sites within the C terminus of FCP1 at Ser-575 and Ser-740 were identified |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250845 |
Ser740 |
TKAQRENsPAAFPDR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12591939 |
We found that only phosphorylated FCP1 can physically interact with TFIIF. We set out to purify an FCP1 kinase from HeLa cells and identified casein kinase 2, which, surprisingly, displayed a negative effect on FCP1-associated activities.| Phosphorylation of FCP1 by CK2 Inhibits the Transcription Elongation Activity of FCP1. | Two in vivo phosphorylation sites within the C terminus of FCP1 at Ser-575 and Ser-740 were identified |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK2B | down-regulates activity
phosphorylation
|
CTDP1 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251063 |
Ser575 |
AGESLDQsMEEEEEE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12591939 |
We found that only phosphorylated FCP1 can physically interact with TFIIF. We set out to purify an FCP1 kinase from HeLa cells and identified casein kinase 2, which, surprisingly, displayed a negative effect on FCP1-associated activities.| Phosphorylation of FCP1 by CK2 Inhibits the Transcription Elongation Activity of FCP1. | Two in vivo phosphorylation sites within the C terminus of FCP1 at Ser-575 and Ser-740 were identified |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251064 |
Ser740 |
TKAQRENsPAAFPDR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12591939 |
We found that only phosphorylated FCP1 can physically interact with TFIIF. We set out to purify an FCP1 kinase from HeLa cells and identified casein kinase 2, which, surprisingly, displayed a negative effect on FCP1-associated activities.| Phosphorylation of FCP1 by CK2 Inhibits the Transcription Elongation Activity of FCP1. | Two in vivo phosphorylation sites within the C terminus of FCP1 at Ser-575 and Ser-740 were identified |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CTDP1 | up-regulates activity 
dephosphorylation
|
WEE1 |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277142 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27670139 |
At mitosis exit, Fcp1 promoted inhibitory Cdk1 phosphorylation by dephosphorylating Wee1, and ubiquitin dependent cyclin B degradation by dephosphorylating Cdc20 and USP44.|This lead us to hypothesize that, during prolonged mitosis in AMCDs treated cancer cells, progressive Fcp1 induced Wee1 reactivation might lead to progressive loss of Cdk1 activity that weakens the SAC to a point in which the mitotic state could not be sustained . |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTDP1 | down-regulates activity
dephosphorylation
|
CDK1 |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277141 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26653855 |
Thus, Fcp1 coordinates Cdk1 and Gwl inactivation to derepress PP2A-B55, generating a dephosphorylation switch that drives mitosis progression.|We can not exclude that, in addition to S90 and S453, other Cdk1 phosphorylation sites in Gwl are dephosphorylated by Fcp1; nevertheless, assaying S67-Ensa kinase activity of V5-GwlS90A and V5-GwlS453A mutant proteins, isolated from transfected and prometaphase arrested HeLa cells, revealed that both mutants had significantly reduced S67-Ensa kinase activity compared to V5-GwlWT (XREF_FIG).|We show here that activation of PP2A-B55, a major mitosis exit phosphatase, required the phosphatase Fcp1 downstream Cdk1 inactivation in human cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CTDP1
- 
- 