| + |
UCHL5 | up-regulates 
binding
|
SMAD7 |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138879 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16027725 |
Here, we report a novel interaction between smads and ubiquitin c-terminal hydrolase uch37, a deubiquitinating enzyme that could potentially reverse smurf-mediated ubiquitination. In gst pull down experiments, uch37 bound weakly to smad2 and smad3, and bound very strongly to smad7 in a region that is distinct from the -py- motif in smad7 that interacts with smurf ubiquitin ligases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UCHL5 | up-regulates quantity by stabilization
binding
|
TGFBR1 |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150135 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17052192 |
Smad7 can act as an adaptor able to recruit uch37 to the type i tgf-beta receptor. Consequently, uch37 dramatically up-regulates tgf-beta-dependent gene expression by de-ubiquitinating and stabilizing the type i tgf-beta receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UCHL5 | up-regulates
deubiquitination
|
SMAD2 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138876 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16027725 |
Here, we report a novel interaction between smads and ubiquitin c-terminal hydrolase uch37, a deubiquitinating enzyme that could potentially reverse smurf-mediated ubiquitination. In gst pull down experiments, uch37 bound weakly to smad2 and smad3, and bound very strongly to smad7 in a region that is distinct from the -py- motif in smad7 that interacts with smurf ubiquitin ligases |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UCHL5 | form complex 
binding
|
INO80 complex |
0.597 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270852 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25016522 |
Here, we have systematically investigated the involvement of the catalytic subunit of the human INO80 complex during unchallenged replication and under replication stress by following the effects of its depletion on cell survival, S-phase checkpoint activation, the fate of individual replication forks, and the consequences of fork collapse. We report that INO80 was specifically needed for efficient replication elongation, while it was not required for initiation of replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UCHL5 | up-regulates activity
deubiquitination
|
SMAD2 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217610 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16027725 |
Here, we report a novel interaction between smads and ubiquitin c-terminal hydrolase uch37, a deubiquitinating enzyme that could potentially reverse smurf-mediated ubiquitination. In gst pull down experiments, uch37 bound weakly to smad2 and smad3, and bound very strongly to smad7 in a region that is distinct from the -py- motif in smad7 that interacts with smurf ubiquitin ligases |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UCHL5 | up-regulates activity
deubiquitination
|
SMAD3 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-232101 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16027725 |
Here, we report a novel interaction between smads and ubiquitin c-terminal hydrolase uch37, a deubiquitinating enzyme that could potentially reverse smurf-mediated ubiquitination. In gst pull down experiments, uch37 bound weakly to smad2 and smad3, and bound very strongly to smad7 in a region that is distinct from the -py- motif in smad7 that interacts with smurf ubiquitin ligases |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
UCHL5
- 
- 