Summary

Name TGFBR1
Full Name TGF-beta receptor type-1
Synonyms TGFR-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, ALK-5, ALK5, Serine/threonine-protein kinase receptor R4, SKR4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I | ALK5, SKR4
Primary ID P36897
Links - -
Type protein
Relations 63
Pathways Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, FAP: TGF beta, Fibrosis, Hepatocellular Tumor, Macrophage: Polarization and myogenesis, Multiple sclerosis, Macrophage: TGF beta, Osteoblast: TGF beta, P38 Signaling, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV MAPK PERTURBATION, SARS-CoV FIBROSIS, Thyroid cancer, TGF-beta Signaling, Thyroid Hormone Metabolism, T-Lymphocyte: TGF beta, TGFb in cancer
Inhibitors SB 505124; SB 431542; 6-[2-tert-butyl-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline; LY-2157299; 452342-67-5
Function Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png deubiquitination TGFBR1 0.2
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation TP63 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TGFBR1 0.703
Publications: 6 Organism: Homo Sapiens, In Vitro, Neovison Vison
Pathways:COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, Thyroid cancer, TGF-beta Signaling, TGFb in cancer
+ down-regulates img/direct_inhibition.png phosphorylation EEF1A1 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD3 0.806
Publications: 3 Organism: Mus Musculus, Homo Sapiens
Pathways:Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Fibrosis, Cell cycle: G1/S phase transition, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, TGF-beta Signaling, Thyroid Hormone Metabolism, TGFb in cancer
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2 0.82
Publications: 3 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), TGF-beta Signaling, TGFb in cancer
+ up-regulates quantity by stabilization img/direct-activation.png binding TGFBR1 0.481
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.525
Publications: 1 Organism: Mus Musculus
Pathways:Thyroid cancer
+ down-regulates img/direct_inhibition.png chemical inhibition TGFBR1 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination TGFBR1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ up-regulates activity img/direct-activation.png binding ZFYVE9 0.613
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ down-regulates activity img/direct_inhibition.png binding TGFBR1 0.729
Publications: 2 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ up-regulates img/direct-activation.png binding TGFBR1 0.264
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination TGFBR1 0.696
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TGFBR1 0.781
Publications: 3 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS, TGF-beta Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition TGFBR1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.356
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), Thyroid Hormone Metabolism
+ down-regulates img/direct_inhibition.png dephosphorylation TGFBR1 0.44
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ down-regulates img/direct_inhibition.png chemical inhibition TGFBR1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination TGFBR1 0.51
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SERPINE1 0.45
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, SARS-CoV FIBROSIS
+ up-regulates img/direct-activation.png binding TGFBR1 0.509
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TRAF6 0.44
Publications: 2 Organism: Homo Sapiens
Tissue: HEK-293T Cell
Pathways:COVID-19 Causal Network, P38 Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition TGFBR1 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TGFBR1 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding TGFBR1 0.845
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ up-regulates img/direct-activation.png phosphorylation TGFBR1 0.703
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, Thyroid cancer, TGF-beta Signaling, TGFb in cancer
+ up-regulates img/direct-activation.png binding TGFBR1 0.425
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TGFBR1 0.734
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ up-regulates img/indirect-activation.png ERK1/2 0.32
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV MAPK PERTURBATION, Thyroid cancer
+ down-regulates img/direct_inhibition.png chemical inhibition TGFBR1 0.8
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png binding TGFBR1 0.838
Publications: 3 Organism: Homo Sapiens
Pathways:Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Cell cycle: G1/S phase transition, P38 Signaling, SARS-CoV MAPK PERTURBATION, Thyroid cancer, TGF-beta Signaling, Thyroid Hormone Metabolism, TGFb in cancer
+ up-regulates activity img/direct-activation.png binding VPS39 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding PIK3R2 0.349
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png RAC1 0.285
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png RHOA 0.624
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SPTBN1 0.495
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding TGFBR1 0.405
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TGFBR1 0.696
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TGFBR1 0.679
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png ubiquitination TGFBR1 0.679
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TGFBR1 0.838
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Cell cycle: G1/S phase transition, P38 Signaling, SARS-CoV MAPK PERTURBATION, Thyroid cancer, TGF-beta Signaling, Thyroid Hormone Metabolism, TGFb in cancer
+ up-regulates img/direct-activation.png binding PIK3R1 0.39
Publications: 1 Organism: Homo Sapiens