Summary

Name MAFB
Full Name Transcription factor MafB
Synonyms Maf-B, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B | KRML
Primary ID Q9Y5Q3
Links - -
Type protein
Relations 6
Function Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ GSK3Bdown-regulates img/direct_inhibition.png phosphorylation MAFB 0.2
Publications: 1 Organism: Homo Sapiens
+ GSK3Bup-regulates img/direct-activation.png phosphorylation MAFB 0.2
Publications: 1 Organism: Homo Sapiens
+ GSK3Adown-regulates img/direct_inhibition.png phosphorylation MAFB 0.2
Publications: 1 Organism: Homo Sapiens
+ PRRX1down-regulates activity img/direct_inhibition.png binding MAFB 0.31
Publications: 1 Organism: In Vitro
+ HOXD12down-regulates activity img/direct_inhibition.png binding MAFB 0.385
Publications: 1 Organism: In Vitro
+ GSK3Aup-regulates img/direct-activation.png phosphorylation MAFB 0.2
Publications: 1 Organism: Homo Sapiens