Summary

Name PTGDR2
Full Name Prostaglandin D2 receptor 2
Synonyms Chemoattractant receptor-homologous molecule expressed on Th2 cells, G-protein coupled receptor 44 | CRTH2, DL1R, GPR44
Primary ID Q9Y5Y4
Links - -
Type protein
Relations 1
Function Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.

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Relations

Regulator Mechanism target score ℹ
+ PTGDR2up-regulates activity img/direct-activation.png binding GNAO1 0.2
Publications: 1 Organism: Homo Sapiens