Summary

Name IGF2BP2
Full Name Insulin-like growth factor 2 mRNA-binding protein 2
Synonyms IGF2 mRNA-binding protein 2, IMP-2, Hepatocellular carcinoma autoantigen p62, IGF-II mRNA-binding protein 2, VICKZ family member 2 | IMP2, VICKZ2
Primary ID Q9Y6M1
Links - -
Type protein
Relations 1
Function RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation IGF2BP2 0.2
Publications: 1 Organism: Homo Sapiens