Relation Results

Summary

Name SLC4A4
Full Name Electrogenic sodium bicarbonate cotransporter 1
Synonyms Sodium bicarbonate cotransporter, Na(+)/HCO3(-) cotransporter, Solute carrier family 4 member 4, kNBC1 | NBC, NBC1, NBCE1
Primary ID Q9Y6R1
Links - -
Type protein
Relations 5
Function Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at th ...
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Type: Score: Layout: SPV 
0.20.20.3540.692PKASLC4A4PP1STK39AHCYL1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PKAup-regulates activity img/direct-activation.png phosphorylation SLC4A4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263158 Ser1026 KKKKKKGsLDSDNDD Mus musculus
pmid sentence
Ser(982) in the C-terminus of kNBC1 is a target for PKA phosphorylation. Phosphorylation of Ser(982) in the sodium bicarbonate cotransporter kNBC1 shifts the HCO(3)(-) : Na(+) stoichiometry from 3 : 1 to 2 : 1 in murine proximal tubule cells Replacing Ser(982) at the C-terminus consensus PKA phosphorylation site with alanine resulted in a failure of PKA to phosphorylate the transporter and induce a stoichiometry shift.
Publications: 1 Organism: Mus Musculus
+ PP1up-regulates activity img/direct-activation.png dephosphorylation SLC4A4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264647 Mus musculus
pmid sentence
WNK kinases acted as scaffolds to recruit SPAK, which phosphorylated CFTR and NBCe1-B, reducing their cell surface expression. IRBIT opposed the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression,
Publications: 1 Organism: Mus Musculus
Tissue: Pancreas
+ STK39down-regulates activity img/direct_inhibition.png phosphorylation SLC4A4 0.354
Identifier Residue Sequence Organism Cell Line
SIGNOR-263133 Homo sapiens HEK-293 Cell
pmid sentence
SPAK phosphorylates the transporters to reduce their surface expression and thus their activity and consequently inhibits ductal secretion to stabilize the resting state. PP1 reverses the effect of SPAK. Molecular analysis revealed that the WNK kinases acted as scaffolds to recruit SPAK, which phosphorylated CFTR and NBCe1-B, reducing their cell surface expression.
Identifier Residue Sequence Organism Cell Line
SIGNOR-264644 Mus musculus
pmid sentence
WNK kinases acted as scaffolds to recruit SPAK, which phosphorylated CFTR and NBCe1-B, reducing their cell surface expression. IRBIT opposed the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression,
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Tissue: Pancreas
+ AHCYL1up-regulates activity img/direct-activation.png binding SLC4A4 0.692
Identifier Residue Sequence Organism Cell Line
SIGNOR-263135 Homo sapiens HEK-293 Cell
pmid sentence
IRBIT opposed the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression, in addition to stimulating their activities.
Publications: 1 Organism: Homo Sapiens
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