Relation Results

Summary

Name denileukin diftitox
Synonyms denileukin diftitox,173146-27-5,DAB(389)IL-2,DAB(389)-IL-2,LY-335348,Ontak,DAB389-IL-2,DAB(389)-interleukin 2,C078456
IUPAC
Formula
Primary ID SID:125240988
Type small molecule
Relations 3

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Type: Score: Layout: SPV 
0.80.80.8denileukin diftitoxIL2RAIL2RGIL2RB

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Relations
Regulator
Mechanism
target
score ℹ
+ denileukin diftitoxup-regulates activity img/direct-activation.png chemical activation IL2RA 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259392 Homo sapiens
pmid sentence
Denileukin diftitox (DAB389IL-2; Ontak) is a novel recombinant fusion protein approved by the US Food and Drug Administration for the treatment of relapsed or refractory cutaneous T-cell lymphoma. It consists of fragments of diphtheria toxin linked to human interleukin-2 and works by targeting the high-affinity interleukin-2 receptor expressed on malignant cells. 
Publications: 1 Organism: Homo Sapiens
+ denileukin diftitoxup-regulates activity img/direct-activation.png chemical activation IL2RG 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259394 Homo sapiens
pmid sentence
Denileukin diftitox (DAB389IL-2; Ontak) is a novel recombinant fusion protein approved by the US Food and Drug Administration for the treatment of relapsed or refractory cutaneous T-cell lymphoma. It consists of fragments of diphtheria toxin linked to human interleukin-2 and works by targeting the high-affinity interleukin-2 receptor expressed on malignant cells. 
Publications: 1 Organism: Homo Sapiens
+ denileukin diftitoxup-regulates activity img/direct-activation.png chemical activation IL2RB 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259393 Homo sapiens
pmid sentence
Denileukin diftitox (DAB389IL-2; Ontak) is a novel recombinant fusion protein approved by the US Food and Drug Administration for the treatment of relapsed or refractory cutaneous T-cell lymphoma. It consists of fragments of diphtheria toxin linked to human interleukin-2 and works by targeting the high-affinity interleukin-2 receptor expressed on malignant cells. 
Publications: 1 Organism: Homo Sapiens
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