| + |
JAK1 | up-regulates activity 
phosphorylation
|
IL2RB |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251342 |
Tyr364 |
SCFTNQGyFFFHLPD |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8700888 |
In COS-7 cells, overexpression of Jak1 augmented phosphorylation of Y338 as well as Y392 and Y510. Y392 and Y510 were critical for IL-2-induced activation of signal transducers and activators of transcription (STAT proteins), Y338 was required for Shc-IL-2Rbeta association and for IL-2-induced tyrosine phosphorylation of Shc. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251340 |
Tyr418 |
LSGEDDAyCTFPSRD |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 8700888 |
In COS-7 cells, overexpression of Jak1 augmented phosphorylation of Y338 as well as Y392 and Y510. Y392 and Y510 were critical for IL-2-induced activation of signal transducers and activators of transcription (STAT proteins), Y338 was required for Shc-IL-2Rbeta association and for IL-2-induced tyrosine phosphorylation of Shc. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251341 |
Tyr536 |
LPLNTDAyLSLQELQ |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 8700888 |
In COS-7 cells, overexpression of Jak1 augmented phosphorylation of Y338 as well as Y392 and Y510. Y392 and Y510 were critical for IL-2-induced activation of signal transducers and activators of transcription (STAT proteins), Y338 was required for Shc-IL-2Rbeta association and for IL-2-induced tyrosine phosphorylation of Shc. |
|
| Publications: |
3 |
Organism: |
Chlorocebus Aethiops |
| + |
LCK |
phosphorylation
|
IL2RB |
0.642 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251375 |
Tyr381 |
EIEACQVyFTYDPYS |
in vitro |
|
| pmid |
sentence |
| 10214954 |
Recombinant p56(lck) phosphorylates in vitro tyrosine residues within the IL-2Rbeta chain. p56(lck) phosphorylates tyrosine residues 355, 358 and 361 but not 338 of the IL-2Rbeta chain acidic subdomain. p56(lck) also phosphorylates very efficiently the two tyrosines present in the IL-2Rbeta chain C-terminal region, Tyr-392 and Tyr-510. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251376 |
Tyr384 |
ACQVYFTyDPYSEED |
in vitro |
|
| pmid |
sentence |
| 10214954 |
Recombinant p56(lck) phosphorylates in vitro tyrosine residues within the IL-2Rbeta chain. p56(lck) phosphorylates tyrosine residues 355, 358 and 361 but not 338 of the IL-2Rbeta chain acidic subdomain. p56(lck) also phosphorylates very efficiently the two tyrosines present in the IL-2Rbeta chain C-terminal region, Tyr-392 and Tyr-510. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251377 |
Tyr387 |
VYFTYDPySEEDPDE |
in vitro |
|
| pmid |
sentence |
| 10214954 |
Recombinant p56(lck) phosphorylates in vitro tyrosine residues within the IL-2Rbeta chain. p56(lck) phosphorylates tyrosine residues 355, 358 and 361 but not 338 of the IL-2Rbeta chain acidic subdomain. p56(lck) also phosphorylates very efficiently the two tyrosines present in the IL-2Rbeta chain C-terminal region, Tyr-392 and Tyr-510. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251378 |
Tyr418 |
LSGEDDAyCTFPSRD |
in vitro |
|
| pmid |
sentence |
| 10214954 |
Recombinant p56(lck) phosphorylates in vitro tyrosine residues within the IL-2Rbeta chain. p56(lck) phosphorylates tyrosine residues 355, 358 and 361 but not 338 of the IL-2Rbeta chain acidic subdomain. p56(lck) also phosphorylates very efficiently the two tyrosines present in the IL-2Rbeta chain C-terminal region, Tyr-392 and Tyr-510. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251379 |
Tyr536 |
LPLNTDAyLSLQELQ |
in vitro |
|
| pmid |
sentence |
| 10214954 |
Recombinant p56(lck) phosphorylates in vitro tyrosine residues within the IL-2Rbeta chain. p56(lck) phosphorylates tyrosine residues 355, 358 and 361 but not 338 of the IL-2Rbeta chain acidic subdomain. p56(lck) also phosphorylates very efficiently the two tyrosines present in the IL-2Rbeta chain C-terminal region, Tyr-392 and Tyr-510. |
|
| Publications: |
5 |
Organism: |
In Vitro |
| + |
denileukin diftitox | up-regulates activity
chemical activation
|
IL2RB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259393 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15757436 |
Denileukin diftitox (DAB389IL-2; Ontak) is a novel recombinant fusion protein approved by the US Food and Drug Administration for the treatment of relapsed or refractory cutaneous T-cell lymphoma. It consists of fragments of diphtheria toxin linked to human interleukin-2 and works by targeting the high-affinity interleukin-2 receptor expressed on malignant cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL15RA | up-regulates
binding
|
IL2RB |
0.799 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157418 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17709786 |
The il-15 receptor comprises a heterotrimeric complex consisting of the common ?cytokine Receptor (?c), the il-2 ? Receptor subunit (il-2r?), And an il-15-specific ? Receptor (il-15r?) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
IL2 | up-regulates
binding
|
IL2RB |
0.869 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144540 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16477002 |
Il-2 is a cytokine that functions as a growth factor and central regulator in the immune system and mediates its effects through ligand-induced hetero-trimerization of the receptor subunits il-2r alpha, il-2r beta, and gamma(c). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL2RB | up-regulates
binding
|
JAK1 |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204972 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell, Lymphoma Cell |
| pmid |
sentence |
| 24737791 |
In lymphocytes, binding of il-15 to the il-2/15rbg heterodimer induces jak1 activation that subsequently phosphorylates stat3 via the b-chain and jak3/stat5 activation via its g-chain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL2RB | up-regulates
binding
|
SHC1 |
0.556 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204975 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell, Lymphoma Cell |
| pmid |
sentence |
| 24737791 |
The signaling mechanism utilizes an adaptor protein, shc, which binds to a phosphotyrosine residue on the il-2/15r?, Resulting in activation of grb2 and onto akt via the shc-grb2-gab2-pi3k-akt signaling pathway to increase cell proliferation and/or survival |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN6 | down-regulates 
dephosphorylation
|
IL2RB |
0.529 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55989 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 9520455 |
We have found that il-2 induces association of shp-1 with the il-2 receptor complex, and that once shp-1 is recruited to the activated receptor it is able to decrease tyrosine phosphorylation of il-2rbeta and the associated tyrosine kinases jak1 and jak3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
125-L-serine-2-133-interleukin 2 (human reduced) | up-regulates activity
chemical activation
|
IL2RB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259389 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18031103 |
Aldesleukin (recombinant IL-2) has similar pharmacodynamic properties to endogenous IL-2 and, when administered to patients with cancer, stimulates the antitumour immune response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IL2RB
- 
- 