| + |
nitric oxide | up-regulates activity 
chemical activation
|
GUCY1A2-B2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243961 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15036565 |
One of the most biologically relevant actions of NO is its binding to the heme moiety in the heterodimeric enzyme, soluble guanylyl cyclase (sGC). Activation of sGC by NO results in the production of the second messenger molecule, 3²,5²-cyclic guanosine monophosphate (cGMP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GUCY1A2-B2 | down-regulates quantity by destabilization 
ubiquitination
|
IDH2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267624 |
|
|
|
|
| pmid |
sentence |
| 34929314 |
During the cell cycle S phase, Cyclin A-CDK2 phosphorylates IDH1 on its Threonine 157 residue (Threonine 197 in IDH2) to facilitate its recognition and ubiquitination by Skp2 E3 ubiquitin, followed by degradation through 26S proteasome |
|
| Publications: |
1 |
| + |
GUCY1B2 | form complex 
binding
|
GUCY1A2-B2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243974 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10977868 |
This enzyme is a heterodimeric protein consisting of - and ²-subunits, and expression of both subunits is required for catalytic activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GUCY1A2 | form complex
binding
|
GUCY1A2-B2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243971 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10977868 |
This enzyme is a heterodimeric protein consisting of - and ²-subunits, and expression of both subunits is required for catalytic activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GUCY1A2-B2 | up-regulates quantity
chemical modification
|
3',5'-cyclic GMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244090 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10977868 |
Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP. The family comprises both membrane-bound and soluble isoforms that are expressed in nearly all cell types |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GUCY1A2-B2