Relation Results

Summary

Name GUCY1A3-B2
Primary ID SIGNOR-C139
Type complex
Formed by GUCY1A1, GUCY1B2
Relations 4

Viewer

Type: Score: Layout: SPV 
0.20.80.80.2GUCY1A1GUCY1A3-B2nitric oxide3',5'-cyclic GMPGUCY1B2

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ GUCY1A1form complex img/form-complex.png binding GUCY1A3-B2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244116 Homo sapiens
pmid sentence
This enzyme is a heterodimeric protein consisting of - and ²-subunits, and expression of both subunits is required for catalytic activity
Publications: 1 Organism: Homo Sapiens
+ nitric oxideup-regulates activity img/direct-activation.png chemical activation GUCY1A3-B2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-244113 Homo sapiens
pmid sentence
One of the most biologically relevant actions of NO is its binding to the heme moiety in the heterodimeric enzyme, soluble guanylyl cyclase (sGC). Activation of sGC by NO results in the production of the second messenger molecule, 3€²,5€²-cyclic guanosine monophosphate (cGMP)
Publications: 1 Organism: Homo Sapiens
+ GUCY1A3-B2up-regulates quantity img/direct-activation.png chemical modification 3',5'-cyclic GMP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-244122 Homo sapiens
pmid sentence
Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP. The family comprises both membrane-bound and soluble isoforms that are expressed in nearly all cell types
Publications: 1 Organism: Homo Sapiens
+ GUCY1B2form complex img/form-complex.png binding GUCY1A3-B2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244119 Homo sapiens
pmid sentence
This enzyme is a heterodimeric protein consisting of - and ²-subunits, and expression of both subunits is required for catalytic activity
Publications: 1 Organism: Homo Sapiens
a simple tooltip