| + |
LHFPL5 | up-regulates activity 
binding
|
Hair cells mechanotransduction channel |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262574 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
Here we show that TMHS is an auxiliary subunit of the hair cells mechanotransduction channel.|TMHS belongs to the tetraspan family. It binds to PCDH15, controls the assembly of the hair cells mechanotransduction machinery, regulates the properties of their mechanotransduction channels, and is required for adaptation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
PIEZO1 | form complex 
binding
|
Hair cells mechanotransduction channel |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262571 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
The pore forming subunits of the hair cells mechanotransduction channel still need to be identified, but some candidates have emerged including TMC-1,TMC-2 (Kawashima et al., 2011), Piezo1 and Piezo2 (Coste et al., 2010; Coste et al., 2012). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
TMC2 | form complex
binding
|
Hair cells mechanotransduction channel |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262570 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
The pore forming subunits of the hair cells mechanotransduction channel still need to be identified, but some candidates have emerged including TMC-1,TMC-2 (Kawashima et al., 2011), Piezo1 and Piezo2 (Coste et al., 2010; Coste et al., 2012). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
Hair cells mechanotransduction channel | up-regulates quantity
relocalization
|
calcium(2+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262573 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
Despite this progress, it is not known which genes encode subunits of the mechanotransduction channel of hair cells. Ca2+ enters stereocilia upon mechanical stimulation near the lower tip-link insertion site, indicating that transduction channels are present in proximity to PCDH15 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TMC1 | form complex
binding
|
Hair cells mechanotransduction channel |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262569 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
The pore forming subunits of the hair cells mechanotransduction channel still need to be identified, but some candidates have emerged including TMC-1,TMC-2 (Kawashima et al., 2011), Piezo1 and Piezo2 (Coste et al., 2010; Coste et al., 2012). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
PIEZO2 | form complex
binding
|
Hair cells mechanotransduction channel |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262572 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
The pore forming subunits of the hair cells mechanotransduction channel still need to be identified, but some candidates have emerged including TMC-1,TMC-2 (Kawashima et al., 2011), Piezo1 and Piezo2 (Coste et al., 2010; Coste et al., 2012). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
3.0
Hair cells mechanotransduction channel