| + |
TIP-LINK complex | up-regulates activity 
binding
|
LHFPL5 |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262580 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
We conclude that the transmembrane and membrane proximal CR domain of PCDH15 mediate interaction with TMHS.|Based on the interdependence of PCDH15 and TMHS for their efficient localization to stereocilia, we reasoned that interaction between the two proteins might regulate their effective cell surface transport. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
MYO7A | form complex 
binding
|
TIP-LINK complex |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262577 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
The adaptor proteins harmonin and SANS, and the motor protein myosin 7a (Myo7a) bind in vitro to each other and to CDH23 (Adato et al., 2005; Bahloul et al., 2010; Boeda et al., 2002; Siemens et al., 2002) and co-localize at the upper insertion site of tip links (Grati and Kachar, 2011; Grillet et al., 2009b), suggesting that they form a protein complex important for transduction. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
USH1G | form complex
binding
|
TIP-LINK complex |
0.597 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262578 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
The adaptor proteins harmonin and SANS, and the motor protein myosin 7a (Myo7a) bind in vitro to each other and to CDH23 (Adato et al., 2005; Bahloul et al., 2010; Boeda et al., 2002; Siemens et al., 2002) and co-localize at the upper insertion site of tip links (Grati and Kachar, 2011; Grillet et al., 2009b), suggesting that they form a protein complex important for transduction. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
PCDH15 | form complex
binding
|
TIP-LINK complex |
0.573 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262575 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
The adaptor proteins harmonin and SANS, and the motor protein myosin 7a (Myo7a) bind in vitro to each other and to CDH23 (Adato et al., 2005; Bahloul et al., 2010; Boeda et al., 2002; Siemens et al., 2002) and co-localize at the upper insertion site of tip links (Grati and Kachar, 2011; Grillet et al., 2009b), suggesting that they form a protein complex important for transduction. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
CDH23 | form complex
binding
|
TIP-LINK complex |
0.639 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262579 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
The adaptor proteins harmonin and SANS, and the motor protein myosin 7a (Myo7a) bind in vitro to each other and to CDH23 (Adato et al., 2005; Bahloul et al., 2010; Boeda et al., 2002; Siemens et al., 2002) and co-localize at the upper insertion site of tip links (Grati and Kachar, 2011; Grillet et al., 2009b), suggesting that they form a protein complex important for transduction. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
USH1C | form complex
binding
|
TIP-LINK complex |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262576 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
The adaptor proteins harmonin and SANS, and the motor protein myosin 7a (Myo7a) bind in vitro to each other and to CDH23 (Adato et al., 2005; Bahloul et al., 2010; Boeda et al., 2002; Siemens et al., 2002) and co-localize at the upper insertion site of tip links (Grati and Kachar, 2011; Grillet et al., 2009b), suggesting that they form a protein complex important for transduction. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
Sound_vibration | up-regulates 
|
TIP-LINK complex |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262581 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
Sound induced vibrations or motion lead to deflection of the stereociliary bundles, which directly control the activity of the mechanotransduction channels in stereocilia. It is thought that tip links, fine extracellular filaments that connect the tips of neighboring stereocilia, transmit tension force onto the transduction channels |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
3.0
TIP-LINK complex