| + |
26S Proteasome | down-regulates quantity 
cleavage
|
Ubiquitinated-Viral_Protein |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267769 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15571818 |
The proteasome system is the central proteolytic system of the eukaryotic cell [1] and plays an important role in the generation of MHC-class I peptides. The enzyme complex responsible for the selectivity of intracellular protein degradation is the 26S proteasome that degrades poly-ubiquitinated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Viral protein | form complex 
binding
|
Ubiquitinated-Viral_Protein |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267765 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25688236 |
MHC class I antigen presentation pathway. Proteins with ubiquitin tags (red spheres) are degraded by proteasomes and the resulting peptides are transported into the endoplasmic reticulum (ER) by TAP|Many viruses have mechanisms of interfering with MHC class I processing, including direct interaction of viral proteins with immunoproteasome subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ubiquitin | form complex
binding
|
Ubiquitinated-Viral_Protein |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267766 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25688236 |
MHC class I antigen presentation pathway. Proteins with ubiquitin tags (red spheres) are degraded by proteasomes and the resulting peptides are transported into the endoplasmic reticulum (ER) by TAP|Many viruses have mechanisms of interfering with MHC class I processing, including direct interaction of viral proteins with immunoproteasome subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ubiquitinated-Viral_Protein | up-regulates activity 
binding
|
26S Proteasome |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267767 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15571818 |
The proteasome system is the central proteolytic system of the eukaryotic cell [1] and plays an important role in the generation of MHC-class I peptides. The enzyme complex responsible for the selectivity of intracellular protein degradation is the 26S proteasome that degrades poly-ubiquitinated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Ubiquitinated-Viral_Protein