| + |
COPS5 | form complex 
binding
|
COP9 signalosome variant 1 |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270775 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18850735 |
The COP9 signalosome (CSN) is a multiprotein complex that plays a critical role in diverse cellular and developmental processes in various eukaryotic organisms. we have performed a comprehensive proteomic analysis of the human CSN complex using a new purification method and quantitative mass spectrometry. Purification of the human CSN complex from a stable 293 cell line expressing N-terminal HBTH-tagged CSN5 subunit was achieved by high-affinity streptavidin binding with TEV cleavage elution. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COPS4 | form complex
binding
|
COP9 signalosome variant 1 |
0.941 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270773 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18850735 |
The COP9 signalosome (CSN) is a multiprotein complex that plays a critical role in diverse cellular and developmental processes in various eukaryotic organisms. we have performed a comprehensive proteomic analysis of the human CSN complex using a new purification method and quantitative mass spectrometry. Purification of the human CSN complex from a stable 293 cell line expressing N-terminal HBTH-tagged CSN5 subunit was achieved by high-affinity streptavidin binding with TEV cleavage elution. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COPS8 | form complex
binding
|
COP9 signalosome variant 1 |
0.925 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270770 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18850735 |
The COP9 signalosome (CSN) is a multiprotein complex that plays a critical role in diverse cellular and developmental processes in various eukaryotic organisms. we have performed a comprehensive proteomic analysis of the human CSN complex using a new purification method and quantitative mass spectrometry. Purification of the human CSN complex from a stable 293 cell line expressing N-terminal HBTH-tagged CSN5 subunit was achieved by high-affinity streptavidin binding with TEV cleavage elution. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COPS3 | form complex
binding
|
COP9 signalosome variant 1 |
0.915 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270769 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18850735 |
The COP9 signalosome (CSN) is a multiprotein complex that plays a critical role in diverse cellular and developmental processes in various eukaryotic organisms. we have performed a comprehensive proteomic analysis of the human CSN complex using a new purification method and quantitative mass spectrometry. Purification of the human CSN complex from a stable 293 cell line expressing N-terminal HBTH-tagged CSN5 subunit was achieved by high-affinity streptavidin binding with TEV cleavage elution. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COPS2 | form complex
binding
|
COP9 signalosome variant 1 |
0.92 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270772 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18850735 |
The COP9 signalosome (CSN) is a multiprotein complex that plays a critical role in diverse cellular and developmental processes in various eukaryotic organisms. we have performed a comprehensive proteomic analysis of the human CSN complex using a new purification method and quantitative mass spectrometry. Purification of the human CSN complex from a stable 293 cell line expressing N-terminal HBTH-tagged CSN5 subunit was achieved by high-affinity streptavidin binding with TEV cleavage elution. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COPS7A | form complex
binding
|
COP9 signalosome variant 1 |
0.914 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270771 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18850735 |
The COP9 signalosome (CSN) is a multiprotein complex that plays a critical role in diverse cellular and developmental processes in various eukaryotic organisms. we have performed a comprehensive proteomic analysis of the human CSN complex using a new purification method and quantitative mass spectrometry. Purification of the human CSN complex from a stable 293 cell line expressing N-terminal HBTH-tagged CSN5 subunit was achieved by high-affinity streptavidin binding with TEV cleavage elution. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPS1 | form complex
binding
|
COP9 signalosome variant 1 |
0.921 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270774 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18850735 |
The COP9 signalosome (CSN) is a multiprotein complex that plays a critical role in diverse cellular and developmental processes in various eukaryotic organisms. we have performed a comprehensive proteomic analysis of the human CSN complex using a new purification method and quantitative mass spectrometry. Purification of the human CSN complex from a stable 293 cell line expressing N-terminal HBTH-tagged CSN5 subunit was achieved by high-affinity streptavidin binding with TEV cleavage elution. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COP9 signalosome variant 1 | up-regulates activity 
binding
|
26S Proteasome |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270795 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26497135 |
The COP9 signalosome (CSN) and the proteasomal LID are conserved macromolecular complexes composed of at least eight subunits with molecular weights of approximately 350 kDa. CSN and LID are part of the ubiquitin–proteasome pathway and cleave isopeptide linkages of lysine side chains on target proteins. CSN cleaves the isopeptide bond of ubiquitin-like protein Nedd8 from cullins, whereas the LID cleaves ubiquitin from target proteins sentenced for degradation. The evolutionary conserved ubiquitin proteasome pathway (UPP) mediates degradation of intracellular proteins in all eukaryotes. This essential process requires three protein complexes: E3 ubiquitin ligases as e.g., cullin-RING ligases (CRLs), CSN and the 26S proteasome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COPS6 | form complex
binding
|
COP9 signalosome variant 1 |
0.928 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270768 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18850735 |
The COP9 signalosome (CSN) is a multiprotein complex that plays a critical role in diverse cellular and developmental processes in various eukaryotic organisms. we have performed a comprehensive proteomic analysis of the human CSN complex using a new purification method and quantitative mass spectrometry. Purification of the human CSN complex from a stable 293 cell line expressing N-terminal HBTH-tagged CSN5 subunit was achieved by high-affinity streptavidin binding with TEV cleavage elution. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
COP9 signalosome variant 1
CPX-1870