| + |
SETD2 | form complex 
binding
|
Iws1:Spt6:CTD complex |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273499 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19141475 |
We showed recently that Spt6, a transcription elongation factor and histone H3 chaperone, binds to the Ser2P CTD and recruits Iws1 and the REF1/Aly mRNA export adaptor to facilitate mRNA export.In vitro, recombinant Spt6 binds selectively to a stretch of uninterrupted consensus repeats located in the N-terminal half of the CTD and recruits Iws1. Thus Iws1 connects two distinct CTD-binding proteins, Spt6 and HYPB/Setd2, in a megacomplex that affects mRNA export as well as the histone modification state of active genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IWS1 | form complex
binding
|
Iws1:Spt6:CTD complex |
0.781 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273497 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19141475 |
We showed recently that Spt6, a transcription elongation factor and histone H3 chaperone, binds to the Ser2P CTD and recruits Iws1 and the REF1/Aly mRNA export adaptor to facilitate mRNA export.In vitro, recombinant Spt6 binds selectively to a stretch of uninterrupted consensus repeats located in the N-terminal half of the CTD and recruits Iws1. Thus Iws1 connects two distinct CTD-binding proteins, Spt6 and HYPB/Setd2, in a megacomplex that affects mRNA export as well as the histone modification state of active genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SUPT6H | form complex
binding
|
Iws1:Spt6:CTD complex |
0.722 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273498 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19141475 |
We showed recently that Spt6, a transcription elongation factor and histone H3 chaperone, binds to the Ser2P CTD and recruits Iws1 and the REF1/Aly mRNA export adaptor to facilitate mRNA export.In vitro, recombinant Spt6 binds selectively to a stretch of uninterrupted consensus repeats located in the N-terminal half of the CTD and recruits Iws1. Thus Iws1 connects two distinct CTD-binding proteins, Spt6 and HYPB/Setd2, in a megacomplex that affects mRNA export as well as the histone modification state of active genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Iws1:Spt6:CTD complex